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Mercaptopurine PDF. In Email
Viết bởi Administrator   
Thứ bảy, 06 Tháng 6 2009 18:29
Còn được gọi là 6-MP, chất đồng đẳng với purine, ở đó sulfur thay thế phân tử oxy của purine và có thể kết hợp vào nucleotide 6-thioIMP, là chất đồng đẳng của inosine monophosphate (IMP); 6-thioIMP ức chế tổng hợp de novo purine ở 2 vị trí, bằng cách ức chế theo kiểu feedback giả bước đầu tiên trong chu trình và bằng cách ức chế sự biến đổi đảo ngược của IMP thành adenine và guanine nucleotide; 6-MP được dùng làm thuốc chống ung thư để điều trị bệnh nguyên bào lympho cấp, bệnh tế bào lympho cấp, và bệnh bạch cầu tủy, dùng qua đường uống. Nó còn được dùng làm thuốc ức chế miễn dịch để điều trị bệnh Crohn, viêm loét kết tràng, viêm khớp vẩy nến cấp tính, và bệnh tăng hồng cầu vô căn. Còn được gọi là 6-mercaptopurine.
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